Fundamentals of cDNA microarray data analysis.

cDNA Microarray Data Normalization

Identification of specific gene expression after exposure to low dose ionizing radiation revealed through integrative analysis of cDNA microarray data and the interactome

Background: Accumulating reports suggest that the biological effects of low- and high- dose ionizing radiation (LDIR and HDIR) are qualitatively different and might cause different effects in human skin. Materials and Methods: To better understand the potential risks of LDIR, we analyzed three cDNA microarray datasets from the Gene Expression Omnibus database. Results: A pathway analysis showed...

Global gene expression analysis using microarray to study differential vulnerability to neurodegeneration

Neurodegenerative disorders such as Parkinson’s disease, motor neuron disease and Alzheimer’s disease is characterized by loss of specific cells within certain regions of the brain. One of the most compelling questions is to determine why specific cell populations are vulnerable to neurodegeneration. We addressed this question by studying global gene expression changes using an animal model of ...

Global gene expression analysis using microarray to study differential vulnerability to neurodegeneration

Neurodegenerative disorders such as Parkinson’s disease, motor neuron disease and Alzheimer’s disease is characterized by loss of specific cells within certain regions of the brain. One of the most compelling questions is to determine why specific cell populations are vulnerable to neurodegeneration. We addressed this question by studying global gene expression changes using an animal model of ...

Standardization of cDNA microarray technology for toxicogenomics; essential data for initiating cDNA microarray studies

In recent years, the DNA microarray has become one of the most powerful tools for toxicogenomic studies. However, microarray technology is still in its early stages, and standardized analytical methods of cDNA microarray analysis have not been clearly established. These differences in methodology can result in data variability in gene expression profiling. Although many analytical methods have ...